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Subject:
From:
Jos Underhill <[log in to unmask]>
Reply To:
Jos Underhill <[log in to unmask]>
Date:
Wed, 28 Sep 2005 22:35:13 +0100
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<<Disclaimer: Verify this information before applying it to your situation.>>

Has anyone had a low T4 level with a normal TSH (so
probably not autoimmune hypothyroidism?), that has resolved
once coeliac has settled down fully?

My T4 is 7 (normal range 8-21) and my TSH is 2.3 (normal
range 0.35 - 3.5). My TTG is 18 (down from 35 three months
ago and 100 at diagnosis in January).


Research so far

I found a study that discovered low thyroxine in children
with coeliac,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d
b=pubmed&dopt=Abstract&list_uids=1437793&query_hl=3
This states that "Serum T4 levels were significantly lower
in children with mucous membrane atrophy...(than in)
children (with) normal gut mucous membrane". However, the
thyroid test I had just before diagnosis (when presumably
the damage was much worse than now) came back normal.

I've read about Euthyroid Sick Syndrome
http://www.merck.com/mrkshared/mmanual/section2/chapter8/8c.
jsp, but I doubt coeliac is sever enough an illness for
this to be the cause. However, this may fit with the
children in the study mentioned previously so maybe it's a
possible cause for low T4 in some adult Coeliacs. The main
reason I don't think this is the case with me, is that the
low thyroxine didn't show up in the blood test just before
diagnosis when damage and malabsorption was at its worst,
but has appeared during recovery.

The only other possibility I've seen for these results is
hypopituitarism but this is rare and I don't like the sound
of it! http://www.umm.edu/endocrin/hypopit.htm

My GP has prescribed Levothyroxine at the lowest dose (25
micrograms) to see if it helps with my continued tiredness
with the intention of testing again in three months.

Will summarize,
thanks,
Jos

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