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Subject:
From:
Jean-Louis Tu <[log in to unmask]>
Reply To:
Paleolithic Eating Support List <[log in to unmask]>
Date:
Sat, 10 Jan 1998 11:22:35 -0500
Content-Type:
text/plain
Parts/Attachments:
text/plain (31 lines)
Ed wrote:

>What levels does the study suggest is needed for
>lowering Lp(a) levels?

In (1), they studied the effect of niacin and neomycin combined, but niacin
alone works too (2).

From (1):

"Neomycin (2g/day) reduced low density lipoprotein cholesterol and lipoprotein
Lp(a) concentrations by 23% and 24%, respectively. Combination
therapy with neomycin (2 g/day) and niacin (3 g/day) induced a 48%
decline in low density lipoprotein cholesterol levels and a 45% reduction
in the concentration of lipoprotein Lp(a)"

From (2):

"This study examines the effect of nicotinic acid (1 g t.d.s.) on serum
Lp(a) concentration in a group of patients with type II hyperlipidaemia
selected on the basis of a plasma Lp(a) concentration greater than 30
mg/dl. Reductions in total cholesterol, triglyceride, LDL-cholesterol
and Lp(a) were 16.3%, 25.5%, 23.7% and 36.4%, respectively, with an
increase in HDL cholesterol of 37.3%."

1. Gurakar A, et al., Levels of lipoprotein Lp(a) decline with neomycin and
niacin treatment, Atherosclerosis. 1985 Nov 1; 57(2-3): 293-301.

2. Seed M, et al., The effect of nicotinic acid and acipimox on lipoprotein(a)
concentration and turnover.

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