People suffering from schizophrenia have brains that lose the ability 
to forget or ignore as much as they normally would. Without 
forgetting, they lose the ability to extract what's meaningful out of 
the immensity of stimuli the brain encounters.

http://scienceblog.com/45099/scientists-afflict-computers-with-schizophrenia-to-better-understand-the-human-brain/ 


Findings suggest that exaggerated prediction-error signaling in 
schizophrenia intermingles and corrupts narrative memories when 
incorporated into long-term storage, thereby disrupting narrative 
language and producing fixed delusional narratives. If further 
validated by clinical studies, these computational patients could 
provide a platform for developing and testing novel treatments.

http://www.biologicalpsychiatryjournal.com/article/PIIS0006322311000126/fulltext 

www.peoplewho.org