Looking at the case studies that are posted on the AACPDM site, it seems as
if the children who were getting the systemic problems or the ones with the
side effects of difficulty with swallowing and breathing, were children who
were GMFCS level V. Children who are GMFCS level V are children who are very
much physically impaired and they usually cannot voluntarily move/control
their head or extremities. I am not a numbers person, but the dosage did not
seem that high in at least one of the reported cases that are posted there.

Either way being a peds PT this new information seems a little scary in that
I want to investigate the issue in greater depth.... Be cautious..

Just wondering, in children generally the dosage of Botox needs to increase
with each round of injections so that the efficacy of the drug is still
present. Does this also need to occur in adults?

Take care,

Greta


On 2/21/08, Kendall D. Corbett <[log in to unmask]> wrote:
>
> Greta,
>
> When I went to see my neurologist yesterday (who's also on the state drug
> utilization review board), I asked him about the botox use in kids issue.
> He said that the kids that died were getting more than 1500 units of botox
> at a time, and it was "spilling over" into their circulatory systems,
> causing botulism poisoning and death.  He only treats adults, and says he
> never goes above 300 units.
>
> I'm presently getting 100 units (total) in my neck and shoulders.
>
> He said the FDA will likely do a "black box warning" on botox (not sure if
> the warning will just apply to kids, or all of us).
>
> I'm curious how much botox others on the list are getting.
>
>
> On 2/20/08, greta von der luft <[log in to unmask]> wrote:
> >
> > Hello,
> >
> > I just received a communication from the American Academy for Cerebral
> > Palsy
> > and Developmental Medicine on Botox. To see it and a listing of
> resources
> > that they have generated go to:
> >
> > http://www.aacpdm.org/index?service=page/fda_announcement
> >
> > Take care,
> >
> > Greta
> >
> > -----------------------
> >
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> >
> >
>
>
> --
>
>
> Kendall
>
> An unreasonable man (but my wife says that's redundant!)
>
> The reasonable man adapts himself to the world; the unreasonable one
> persists in trying to adapt the world to himself. Therefore, all progress
> depends on the unreasonable man.
>
> -George Bernard Shaw 1856-1950
>
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>
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>
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