Alex Shvartsman wrote:

>[Cordain] Finally, at the molecular level saturated fats
>have been shown numerous times to down regulate the LDL receptor by their
>direct influence upon gene transcription for the LDL receptor proteins.  This
>evidence is the "smoking gun" which most lay readers are unaware or don't
>understand.
>
>

This is correct, and a Nobel prize was awared for this discovery some
years back.

The unresolved issue, however, is whether an increase in LDL is, in
itself, cause for concern.  Cordain and the vast majority of scientists
think it is, but clearly there are dissenters.  If the dissenters are
right, it isn't a smoking gun after all, but only a neutral side-effect.

Todd Moody
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