<<Disclaimer: Verify this information before applying it to your situation.>> My biopsy experience (I had two) wasn't bad either. I have an incredible fear of anything like this, and was a total baby about doing it. The nurses brought in warm blankets to calm me (I was shivering with fear). The Dr. gave me a light sedative, with some amnesia medicine added. I swallowed some bitter tasting stuff, they sprayed my throat, and I was out. Woke 30 minutes later and don't remember anything... The second go round I reminded the Doctor about 5 times that I wanted the experience to be exactly the same...and It was..not a big deal..