<<Disclaimer: Verify this information before applying it to your situation.>> Dream of it. Eat lasagne & take a pill w/o getting sick. Now that would be a dream come true! I have my doubts that a gluten/gliadin splitting enzyme pill will ever prevent a celiac from reacting to gluten. I would think the enzyme would have to completely mix with & totally digest ALL the gluten/gliadin in the food before the gluten/gliadin comes in contact with the mucous membranes of the GI track. Once a person has become sensitized to gluten/gliadin, very tiny amounts can cause a reaction in any part of the GI track in a very short period of time. I've heard of some celiacs reacting almost instantly to an accidental ingestion. I seriously doubt an enzyme that is swallowed before or during a glutenous meal could work fast enough to prevent the gluten/gliadin from coming in contact with the mucous membranes. I hope I'm wrong. It seems to me that the enzyme would have to be mixed with the gluten containing food before it even enters the mouth. May be, just, may be, the pill could prevent a non reactive, but genetically predisposed person from becoming a celiac by reducing the overall exposure to gluten in the first place. I think what might work better, would be a drug that somehow targets the part of the immune system that reacts to gluten/gliadin. Something like an antihistamine for allergies or a immune suppressor for autoimmune inflammatory conditions. But I can't imagine something like that being safe to use long term. Antihistamines & immuno suppressive drugs are laden with unpleasant & harmful side effects. I doubt a drug that suppresses the specific autoimmune reaction in celiac would be any safer or more pleasant. But ... who know? We need more research. I hope the possibility of such products attracts the attention of pharmaceutical companies. If it does & they see it as potentially profitable, then tons of $$$$$ will pour in for celiac research. That in turn will mean more education about celiac disease reaching the dulled ears of American doctors. When the drug reps start coming into clinics and continuous education seminars & telling the doctors that they have a new pill for celiacs and that celiac disease is really a very, very common disease, that will make doctors more eager to seek out celiacs among their patients. And that would definitely be a good thing! Any opinions or comments? ~Valerie in Tacoma, WA ________________________________________________________________ GET INTERNET ACCESS FROM JUNO! Juno offers FREE or PREMIUM Internet access for less! Join Juno today! For your FREE software, visit: http://dl.www.juno.com/get/web/. * Visit the Celiac Web Page at www.enabling.org/ia/celiac/index.html *