<<Disclaimer: Verify this information before applying it to your situation.>> Thanks to all of you for your wonderful responses. The majority of you said that I need to add B vitamins to my daily routine and that Angular Cheilitis is caused most of the time due to B vit deficiency. I started a Vitamin B complex yesterday and can see a major change in the blisters and rash already today. It's been on my face for almost three weeks with no change inspite of all the topical things I tried. The Vit B complex is certainly helping. Thanks! Jill/Texas