<<Disclaimer: Verify this information before applying it to your situation.>> Hi, Here's some of my experiences. In the case of the Celiac the immune system boosts an unwanted response. This response damages the stomach lining and/or leads to a stressed liver. The response can be avoided by following a GF diet. Also the liver needs to be rested. This means no alcohol, no vitamins, no concentrated juices, no spices, no chillies, little salt, little toothpaste, no fizzy drinks or squashes, etc. Just a very plain and basic diet only. Once the liver picks up then probably it is safe to consume more nutritional foods which are GF. The liver could take months to fully recover. A poorly functioning liver creates lethargy, poor energy, tiredness, dizzieness, headaches similar to a hangover, 'woozieness'. Headaches can come from this (because the liver pushes un- metabolised substances into the blood stream) and from lack of salt, which enables a build up of fluid which puts pressure the brain. A damaged stomach lining will create digestion difficulties and pain. It will lead to an instant drop in all round energy levels and a sudden feeling of weakness. It will also be prone to acid problems. This can show up with products such as fizzy drinks containing Aspartame or Nutrasweet, or even ordinary Fizzy drinks as well. Undigested matter can become a haven for undesirable bacteria which then can cause Bowel problems such as IBS, Crohns, Collitis, etc. There is a study which shows that a modern more hygienic society leads to an unwanted response. The immune response has little to occupy it so it finds stimuli elsewhere. This could be Gluten, pollen, pollution, dust, etc. The study also shows that people or children exposed to traditional stimuli are less likely to develop unwanted responses. The pace of modern living also produces more stress. Stress has an impact also on the immune system. Toxin also affects the immune response. This may sound obvious. A source of toxin can be one's filling for example. Acid(e.g. from an apple) combined with salt(from a bag of salted fries) can release gaseous toxin from fillings via saliva into the stomach and lungs. Generally a happier person has far greater effective immunity. An ineffective but strong immune response can lead to e.g. Celiacs and diabetes, etc. A weak immune response leads to more bacterial & viral infections as well as colds & flu, etc. Sustained toxin ingestion will trigger a strong and effective immune response continually and will also lead to stomach, liver and lung problems already highlighted. So: (Genetic/hereditary, Environment, Stress, Illness, Accident, Radiation, Poisoning) --> -->(Particle/Gluten Rejection and Allergy) ---> (Unwanted Immune Responses) --> -->(Stomach, Liver, Lungs and Bowel problems) --> -->(Poor digestion, loss of strength, lethargy, tension/on edge, poor sleep, poor breathing, poor concentration, poor bowel movements, etc) Gluten problems result in an attack on the small intestine, the bowel and the liver as well as the blood stream. Poor energy conversion also means poorly oxygenated blood. This can lead to breathing problems and brain cell destruction. Gluten unfortunately can elicit an immune response almost immediately. There are however products which retard the immune response. Combine this which a substance which breakdowns the Gluten into a more fundamental substance fairly quickly then maybe an effective preventative medicine could be created. For now a Celiac has no choice but to stay away from Gluten and/or stress. I wonder if it is possible to retrain the immune response to ignore Gluten? Conditioning may play a role in this. PS Are there any Celiacs who have noticed that they have began 'wheezing' when breathing hard? Cheers, Anand.