<<Disclaimer: Verify this information before applying it to your situation.>> Sorry to take awhile with this but we took off for Colorado for a week to get away from this heat wave we are having in Texas...managed to bring back some cooler weather! No one who responded had tried the Miacalcin and Evista combo that my doc had prescribed so I contacted the National Osteoporosis Foundation and got a nice reply saying that there is a lack of available data to suggest that the combination of these two therapies would be more beneficial than either therapy alone, nor do they know anything about the risk/benefit profile of taking these two medicines. So I have decided not to try and mix them. Two people mentioned problems with leg cramps/blood clot problems with the Evista and several suggested I try the new once/week dosage of Fosomax. Seems they are having good luck with it...no bad esophageal problems. One person wrote that Procter and Gamble is coming out with a new drug that works as well as Fosomax but without the esophageal problems, but she/he could not remember the name of the product...I wasn't able to find anything on it when I checked the latest meds that are on trial. Several people responded that they have had good results with the Miacalcin after taking it for 3 years...no additional bone loss and some improvement in rebuilding. One person reported having nosebleeds. One person takes a combination of Miacalcin and DHEA that seems to work for her. I took Miacalcin a little over 2 years ago but had to stop because of nosebleeds and severe irritation of one nostril...but my ENT doc says that is all cleared up now and it wouldn't hurt to try again. Because of my previous problems with the Miacalcin and because the NOF did NOT recommend mixing it and the Evista I have decided to stick with the Evista only until my next appointment, at which time I will ask my doctor about the new once or twice a week dosages of Fosomax . Thanks to all who responded...and good luck to you all! Elizabeth