<<Disclaimer: Verify this information before applying it to your situation.>> It seems that several people on the list have little luck with the current proton pump inhibitors such as Prevacid and Prilosec. This article in Medscape might be interesting for them -- or not: It does have some interesting positive info about the safety of these drugs in general. It is also beneficial to healing GERD. -vance Study shows rabeprazole provides first-dose heartburn relief In a study presented at the annual Digestive Disease Week (DDW) meeting, patients with non-erosive reflux disease (NERD) experienced significant symptom improvement for both daytime and night-time heartburn after taking rabeprazole (Pariet/Aciphex). http://gastroenterology.medscape.com/22411.rhtml