<<Disclaimer: Verify this information before applying it to your situation.>>

Feedback sought regarding Enterolab report. It is a little confusing to read, but two things struck me: one, the gene test is done somewhere else, and two, has anyone else ever heard of the notion that there are genes that predispose to Celiac but are not the known Celiac genes? It was my understanding that Prometheus looks not only for the main two genes that are known, but also a third which to date has succeeded in identifying Celiac in all biopsy-diagnosed Celiacs who previously had negative gene test results. Dr. Fine seems to be saying  he can find yet another set of  genes which predispose to Celiac.
I wonder if anyone else knows anything authoritative about this. 
I have cut and pasted the two key points. I was unable to include the full Enterolab results due to list length restrictions on posts, but have tried to leave as much as possible for informational purposes.
Thanks.
I will post a summary of responses. 
Hilary

"Molecular Gene Analysis performed by: Laboratories at Bonfils"

"Although you do not possess the main genes predisposing to celiac sprue 
(HLA-DQ2 or HLA-DQ8), HLA gene analysis reveals that you have a 
genotype 
that predisposes to gluten sensitivity [either HLA-DQB1*03xx (HLA-DQ3, 
not 
0302), or any HLA-DQB1*05xx or any HLA-DQB1*06xx (HLA-DQ1)]."



Final Laboratory Report

Date:  1/7/06
Gluten Sensitivity Testing
Fecal Antigliadin IgA     15 Units     (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA     12 Units   (Normal Range <10 
Units)

Microscopic Fecal Fat Score:  135 Units   &nbs! p; (Normal Range < 300 Units)

HLA-DQ Gene Molecular analysis:  HLA-DQB1*0301, 0301


Analysis of this stool sample indicates you have dietary gluten 
sensitivity. For optimal health and prevention of small intestinal 
damage, 
osteoporosis, damage to other tissues (like nerves, joints, pancreas, 
skin, 
liver, am! ong others), and malnutrition, recommend a strict gluten free 
diet. If you are experiencing any symptoms, these may resolve following 
a 
gluten free diet.  As gluten sensitivity is a genetic syndrome, you may 
want to have your relatives screened as well.

Although you do not possess the main genes predisposing to celiac sprue 
(HLA-DQ2 or HLA-DQ8), HLA gene analysis reveals that you have a 
genotype 
that predisposes to gluten sensitivity [either HLA-DQB1*03xx (HLA-DQ3, 
not 
0302), or any HLA-DQB1*05xx or any HLA-DQB1*06xx (HLA-DQ1)].

The numeric value of an antibody is not a measure of clinical 
severity.  Values of 10 Units can be associated with the same reactions 
as 
the maximum values we measure (200-300). Most positive reactions are 
between 20 and 80 Units. An analogy would be trying to use the level of 
antibodies to penicillin in a person who has had an allergic ! reaction 
to 
penicillin to determine if it would be safe for them to take penicillin 
again. This obviously is not done because those with demonstrated 
penicillin allergy could not take penicillin without the risk of 
suffering 
severe health consequences. Although gluten sensitivity is not a true 
allergy like penicillin allergy, the concept is the same.


Interpretation of Fecal IgA to the Human Enzyme Tissue 
Transglutaminase: 
Values greater than or equal to 10 Units indicate that the immune 
reaction 
to gliadin has resulted in an autoimmune reaction to the human enzyme 
tissue transglutaminase. It is this autoantibody that may be 
responsible 
for the many autoimmune diseases associated with gluten sensitivity.
Interpretation of Quantitative Fecal Fat Microscopy:  A fecal fat score 
less than 300 indicates there is no malabsorbed dietary fat in stool 
indicating that digestion and absorption of nutrients is normal.

Interpretation Of HLA-DQ Testing by Molecular Analysis and Conversion 
to 
"Serologic Equivalent":  Today HLA-DQ gene testing is done by analyzing 
DNA 
using molecular techniques. In the past, the methods were done by 
analyzing 
blood cells for the antigens produced by the genes, and these past 
methods 
were responsible for the most commonly known nomenclature for HLA-DQ 
genes 
even today (using integers such as "DQ2"). These are called "serologic 
equivalents" to the specifically analyzed gene material. The serologic 
equivalents are as follows:

* If the first two numbers of the molecular type are 05, the serologic 
equivalent is DQ1 subtype DQ5
* If the first two numbers of the molecular type are 06, the serologic 
equivalent is DQ1 subtype DQ6
* If the molecular type is 0201, the serologic equivalent is DQ2 * If 
the 
molecular type is 0301, the serologic equivalent is DQ3 subtype DQ7
* If the molecular type is 0302, the serologic equivalent is DQ3 
subtype DQ8
* If the molecular type is 0303, the serologic equivalent is DQ3 
subtype DQ9
* If the first two numbers of the molecular type are 03 but it is not 
0301, 
0302, or 0303, the serologic equivalent is DQ3
* If the first two numbers of the molecular type are 04, the serologic 
equivalent is DQ4

The gluten sensitive, celiac genes are HLA-DQB1*0201 and HLA-DQB1*0302 
(HLA-DQ2 and HLA-DQ8, respectively).

The other gluten sensitive genes are any molecular type involving 
another 
HLA-DQB1*03 number (i.e., HLA-DQ3), or any HLA-DQB1*05 number, or any 
HLA-DQB1*06 n! umber (i.e., HLA-DQ1)

If you have one gluten sensitive gene, then your offspring have a 50% 
chance of receiving the gene from you, and at least one of your parents 
passed it to you. Having two copies of a gluten sensitive or celiac 
gene, 
means that each of your parents, and all of your children (if you have 
them) will possess at least one copy of the gene. Two copies also means 
there is an even stronger predisposition to gluten sensitivity than 
having 
one gene and the resultant immunologic gluten sensitivity or celiac 
disease 
may be more severe.
For more information about result interpretation, please see 
http://www.enterolab.com/What_Happens

Stool Analysis performed by: Frederick Ogunji, Ph.D., EnteroLab
Molecular Gene Analysis performed by: Laboratories at Bonfils
Interpretation of all results by: Kenneth D. Fine, M.! D., EnteroLab

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