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Subject:
From:
Kelly Dube <[log in to unmask]>
Date:
Mon, 1 Apr 2002 10:49:48 -0500
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<<Disclaimer: Verify this information before applying it to your situation.>>

Here is a recent abstract on lymphoma and celiac disease.

Kelly in Michigan (husband Steve, stage IV, NHL)

Risk of non-hodgkin lymphoma in celiac disease.

JAMA 2002 Mar 20;287(11):1413-9

Catassi C, Fabiani E, Corrao G, Barbato M, De Renzo A, Carella AM,
Gabrielli A, Leoni P, Carroccio A, Baldassarre M, Bertolani P, Caramaschi
P, Sozzi M, Guariso G, Volta U, Corazza GR.

University of Maryland, Division of Pediatric Gastroenterology and
Nutrition, 22 S Greene St, N5W70/Box 140, Baltimore, MD 21201. [log in to unmask]

CONTEXT: Celiac disease is one of the most common lifelong disorders.
Non-Hodgkin lymphoma is a possible complication of celiac disease and may
lead to a large portion of lymphoma cases. OBJECTIVE: To quantify the risk
for developing non-Hodgkin lymphoma of any primary site associated with
celiac disease. DESIGN AND SETTING: Multicenter, case-control study
conducted between January 1996 and December 1999 throughout Italy.
PATIENTS: Cases were older than 20 years (median, 57; range, 20-92 years)
with non-Hodgkin lymphoma of any primary site and histological type and
were recruited at the time of the diagnosis. Controls were healthy adults
(2739 men and 2981 women) from the general population. MAIN OUTCOME
MEASURE: Positive test result for class A serum antiendomysial antibody.
RESULTS: Celiac disease was diagnosed in 6 (0.92%) of 653 patients with
lymphoma. Of the 6 cases, 3 were of B-cell and 3 were of T-cell origin.
Four of 6 cases had lymphoma primarily located in the gut. In the control
group, 24 (0.42%) had celiac disease. The odds ratio (adjusted for age and
sex) for non-Hodgkin lymphoma of any primary site associated with celiac
disease was 3.1 (95% confidence interval [CI], 1.3-7.6), 16.9 (95% CI,
7.4-38.7) for gut lymphoma, and 19.2 (95% CI, 7.9-46.6) for T-cell
lymphoma, respectively. The risk for non-Hodgkin lymphoma for the overall
population, which was adjusted for age and sex, was 0.63% (95% CI, - 0.12%
to 1.37%). CONCLUSION: Celiac disease is associated with an increased risk
for non-Hodgkin lymphoma, especially of T-cell type and primarily localized
in the gut. However, the association does not represent a great enough risk
to justify early mass screening for celiac disease.

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