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One more:
Dig Dis Sci. 2008 Feb;53(2):500-5. Epub 2007 Jun 28.
Co-occurrence of IgA antibodies against ethanol metabolites and tissue transglutaminase in alcohol consumers: correlation with proinflammatory cytokines and markers of fibrogenesis.
Koivisto H, Hietala J, Anttila P, Niemelä O.
Source
Medical Research Unit and Department of Laboratory Medicine, Seinäjoki Central Hospital, Seinajoki 60220, Finland.
Abstract
IgA antibodies to tissue transglutaminase have been suggested to be specific indicators of celiac disease. However, no studies have addressed the relationships between such antibodies and alcohol abuse, which is also a common cause of IgA-isotype immune responses and tissue injury in the gastrointestinal tract and liver. Here, measurements of specific IgAs against tissue transglutaminase and proteins modified by acetaldehyde, the first metabolite of ethanol, showed significantly higher levels of both antibodies in alcoholic liver disease patients than in healthy controls or heavy drinkers without liver disease. These antibodies also significantly co-occurred in heavy drinkers without liver disease, moderate drinkers, and abstainers, and correlated with biomarkers of alcohol consumption, proinflammatory cytokines and markers of fibrogenesis. The data suggests a link between such immune responses, perturbations in cytokine profiles and fibrogenesis,
which should be implicated in studies on the pathogenesis and diagnosis of ethanol-induced tissue injury and celiac disease.
PMID:
17597408
[PubMed - indexed for MEDLINE]
There was one person who took offense to my question about a possible relationship between celiac disease and alcoholism. I did not mean to offend. I myself am the daughter and granddaughter to a host of alcoholics. I should like to offer that it is now well-known that alcoholism is a disease, not a moral failing. Many believe it is an allergy to alcohol. The gene markers are now identifiable, and even in use. It is also known that when a person with alcoholism drinks alcohol, a type of morphine is produced in their brain.
Thank you all for generously answering.
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