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Date: | Thu, 15 Nov 2007 12:34:43 -0500 |
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<<Disclaimer: Verify this information before applying it to your situation.>>
I woud really like to use melatonin regularly and so watched the post with
interest. I also did some further reading and research for my own use.
Ray Sahelian, MD in his book Melatonin: Nature's Sleeping Pill says" Since
melatonin improves and stimulatest he immune system, it couild possibly have
detrimental effects in conditions where the immune system is already out of
control. These include autoimmune diseases such as systemic lupus
erythematous or lymphoproliferative conditions such as leukemias and
lymphomas. Persengiev (1993) reports melatonin administration in vitro
(test tube) caused and increase in myeloma cell proliferation. "
Given our propensity for other autoimmune diseases like rheumatoid arthritis
and diabetes, as well as our risk for lymphomas there does seem a good
reason for caution.
I also found the following links:
http://autoimmunedisease.suite101.com/article.cfm/melatonin_in_autoimmune_disease
http://www.wholehealthmd.com/ME2/dirmod.asp?sid=17E09E7CFFF640448FFB0B4FC1B7FEF0&nm=Reference+Library&type=AWHN_Supplements&mod=Supplements&mid=&id=494D7543D6CA42AB987FE5CC3A6C9D0B&tier=2
Also this article:
Pathobiology 1997 ; 65(4)190-4. Luzindole, a melatonin receptor antagonist,
suppresses experimental autoimmune encephalomyelitis.
C S Constantinescu
B Hilliard
E Ventura
A Rostami
Department of Neurology, University of Pennsylvania, Philadelphia, USA.
[log in to unmask] Melatonin has immune-enhancing effects and can
exacerbate autoimmunity. Pinealectomy or light exposure, which suppress
melatonin, inhibit T cell autoimmunity. To investigate the involvement of
melatonin in experimental autoimmune encephalomyelitis (EAE), a
T-cell-mediated autoimmune demyelinating disease, we tested the effect of
luzindole, a melatonin receptor antagonist, on EAE. Luzindole-treated mice
did not develop EAE after immunization with spinal cord homogenate, whereas
control mice developed EAE. This study suggests that pharmacological
inhibition of the immunoenhancing effects of melatonin may prevent
autoimmune demyelination. MedlineID:
PMID: 9396042
The full text of this article may be accessible through PubMed at:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9396042&dopt=Abstract
Thought list mates would want to see this info as well.
Jane
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