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From THE INFORMED PATIENT column at wsj.com By LAURA LANDRO

Help Is on the Way For Your Skeleton
Coming Drugs and Treatments For Osteoporosis Rebuild Bones Instead of Just
Slowing Loss
July 15, 2004

Doctors and researchers are trying a new approach to the crippling and
painful loss of bone that people, particularly women, experience as they
age: rebuilding bones instead of merely trying to slow their deterioration.

The new techniques for treating osteoporosis and low bone density involve
everything from vibrating-motion therapy -- an idea being tested by the Army
-- to powerful new drugs that can stimulate new bone formation. The goal is
to manipulate the natural cycle by which bones destroy and rebuild
themselves over a lifetime.

One of these bone-building drugs is on the market, and a second will be
available soon. Drug companies are developing therapies based on newly
discovered genes that aid in bone formation, as well as creating more
powerful and effective versions of existing drugs. All told, six new
osteoporosis drugs will be on the market in the next four years, and many
more are in the pipeline; there are nearly 600 osteoporosis trials listed on
recruitment and government Web sites.

At a recent meeting of the American Society for Bone and Mineral Research,
researchers presented a slew of new evidence on bone-building therapies they
say will revolutionize the treatment of osteoporosis and eventually could
eliminate it. "For the last 20 years, we've been trying to hold on to
whatever bone people have," says Clifford Rosen, director of the Maine
Center for Osteoporosis Research and Education. "Now the paradigm has
shifted totally to say we can rebuild the skeleton and make it like new
again."

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