<<Disclaimer: Verify this information before applying it to your situation.>> Thanks to everyone who responded to my query regarding any reactions people may have with Nature Made vitamins. I received about 20 responses. About 2/3 of those responding indicated no problem with Nature Made. Two indicated possible reactions they suspected were caused by Nature Made. Three indicated trouble with any vitamins - even gluten free ones. Respondents indicated the following: - that vitamins can cause "pill gastritis" by making it to the small intestine before disolving completely. - that powder or gell vitamins might be more easily digested - the Freeda and Twin Labs vitamins are a good source of gf vitamins - that vitamin C in large doses can act as a laxative, Calcium in large doses can cause cause digestive problems as well Hope this is helpful! 8-) Debbie