<<Disclaimer: Verify this information before applying it to your situation.>> I believe Karen's point about the biopsy being a definitive diagnosis is wrong. In my reading and my visits with my GI, I again and again heard that the conclusive diagnosis to CD is a remission of symptoms on a gf diet. My GI said this would be true even if blood work and a biopsy were positive. If symptoms conclusively go into remission on a gf diet, then a gf diet is the cure. And if symptoms are inherently linked to a non-gf diet, then I would say the person has CD. I am self diagnosed recently. My GI could not find evidence of sprue in blood work or a biopsy. But eating a gf diet has put my symptoms in remission. If there are others of you who are self diagnosed, please send me your stories, because, despite the above notice, I worry that Karen is right, and without a solid diagnosis from an "educated doctor" I shouldn't be wasting my time, effort, and money on eating gf. Christopher Tyler