<<Disclaimer: Verify this information before applying it to your situation.>> In July 1997 I sent the following to the list: This is in answer to a letter from Leslie, questioning the wisdom of gluten challenge when she becomes violently ill if she accidentally ingests gluten. I have the same question, tho in my case the violent reaction is mental as well as physical. I do vomit, have diarrhea, etc., but I also become irrational, angry, and a pain to be around. I have adamantly refused biopsy again and again. The hard thing about it is that the doctors are annoyed when a patient refuses to "cooperate." Never mind that the doctors are refusing to cooperate with us. Who's paying, anyhow, and who's sick? Would a doctor knowingly eat something that might make him/her suicidal? Or would he/she eat something that might threaten a job loss because of irratic behavior. With symptoms very related to schizophrenia in some patients (and that includes me), isn't it more than a little dangerous to do a gluten challenge for those persons - or perhaps for anyone who has found relief in a gluten-free diet? If that is the case, what are the alternative ways to determine whether or not one is indeed a celiac , and is it important to know that, if one knows that gluten-containing foods cause mental and physical symptoms? Is it possible that gluten-induced change would become irreversible? That a challenge might cause lasting damage? What if brain damage is the long term result? Do the medical professionals really know the answers to these questions? Gayle Kennedy NOW THE IMPORTANT RESPONSE FROM Dr. Gary Kiefer "Good for you. I am a Dr. but a good one who happens to agree with you 100%. I am trying to substantiate these biopsy tests to determine if in fact they are important to help the patient or important to line the pockets of the doctors. I'm with you. Take care. Dr Gary" [log in to unmask] I do not know Dr. Gary Keifer, and this is our only communication, but I think his message is worth repeating for those wondering about a gluten challenge and a biopsy, after one has been gluten-free for some time. Gayle Kennedy