<<Disclaimer: Verify this information before applying it to your situation.>> I am a patient, presenting 90% of the clasic symptoms of Sprue, In a Upper Gi, and an endoscopy test, I presented "visual signs" of Sprue, however the biopsy did not reveal Sprue. I have experimented with alternating days of a wheat including diet, and a wheat excluding diet. On days with no wheat, i experienced less discomfort, as well as a decrease in symptoms, and on wheat inclusive days I experienced an increase in symptoms. I am curious if despite the biopsy's findings if it is possible that I still do have Sprue. I am also curious if there is any corolation between Sprue and depression, specifically Bi-Polar disorder. I am also curious about any relationship Sprue may have with dehydration, and or asthma. thank you for your time