<<Disclaimer: Verify this information before applying it to your situation.>> I just spoke with a representative from WAyerst Labs in Philadelphia, makers of Premarin and Premphase. She told me that all the medications made by WAyerst are gluten free. She seemed to know what she was talking about, as her own child in intolerant to gluten. She got her information from the quality control expert at WAyerst, at 800-999-9384, extension #3. Sherill Roberts McMinnville, Oregon