<<Disclaimer: Verify this information before applying it to your situation.>> Recently, a person posted a message about having leg cramps or discomfort after going off gluten. I cannot find her personal address. When I went off gluten, I also continued to have leg cramps and pain that felt like it was in the bone or deep muscle. The doctors said something about restless leg syndrome or calcium deficiency. I found it was neither. It was intolerance of soybean. This is how I discovered I had both gluten and soy problems. Perhaps others have more than one problem. It takes time to try different withdrawals and challenges, but if a symptom persist it might be a place to look. I had just a little soy in progesterone capsules I was prescribed. It took just a few hours before my legs cramped up. The drug company told me the capsule did not have soy at first, then determined that it did. This lead to another problem that has been discussed. Since my doctor who treats me for adrenal insufficiency wanted me on natural progesterone, soy was the only choice, until Women's International Pharmacy told me about topical progesterone in a cream form. You just rub it on your skin once a day. My gyn felt it would not work. It would not deliver enough progesterone. He was wrong. My levels with the cream were good. This means that WHAT WE RUB ON OUR SKIN CAN BE ABSORBED. Nicotine patches are another example of absorption through the skin. Therefore gluten can be absorbed also. I had gluten like reactions from wall papering and had to let my husband finish the job. It never occurred to me I was handling wheat paste.