<<Disclaimer: Verify this information before applying it to your situation.>> Hi, I'm new to the list and am therefore unsure as to what is usually discussed. My wife was diagnosed as celiac in January this year through a colonoscopy and biopsy (I think those are the terms). She had all the usual symptoms (from what I have read) - stomach rumblings, diarrea, abdominal pains. These symptoms she has had for 30 years, but has only this year been diagnosed as celiac. It was only the fact that she suffered weight loss that the doctors agreed to do the GI testing which diagnosed the condition. Over the last six months, she has followed a gluten-free diet and consquently put all the previous lost weight back on and is now at her normal weight. Some of the other symptoms did improve slightly eg stomach rumblings, but the diarrea still persists. Her consultant has been baffled at the persistence of the symptoms (he had never had a patient not respond to a gf diet) and has carried out a second biopsy...This has confrimed that there is some inflamation, which he says is not normal (whatever that may mean), and that a second colonoscopy should take place (next week). I guess my questions are: 1. Could CD have been misdiagnosed in the first instance? (The biopsy showed the absence of the villi)...are there any other conditions that show similar damage to the intestinal wall? 2. Could it be that she just may not respond to a gf diet...and if so is there a solution...I have read about the use of steroids...is there anybody else on the list who has failed to respond to gf diet, and has to use drugs, and if so how does it affect their quality of life. As you can appreciate, we are very worried about a misdiagnosis or something worse and any information and help you could provide wold be of great help. For information, my wife's age is 35. Thanks all in advance, Mike _____________________________________________________________________ Sent by RocketMail. Get your free e-mail at http://www.rocketmail.com