<<Disclaimer: Verify this information before applying it to your situation.>> Hi, I am new to the list, and am having trouble with my own diagnosis. I have read the web pages, but I think you who have 'been there' can possibly help more. My symptoms are not debilitating, nor am I thin and wasting away<G>... I do have the diahhrea, depression, lethargy , b12 and Iron deficiency... About three months ago a Gastro doctor after hearing my symptoms said "you probably have Sprue... have your Fam Dr do the blood test. ... weeks passed, during which time I read up, and eliminated Wheat products, and was THRILLED with the improvement.. at this point the Fam Dr had not followed up, so I pursued it, and at a visit he said 'you don't look SICK enough to have CD'. But he scheduled the Blood test and a Small Bowel Follow Thru. I did go back on wheat for 3 weeks prior to the tests. I apparently 'failed' to show the necessary symptoms of Sprue/ CD, and thus he feels I do not have it. I am happy to stay off of Wheat, and to suffer the consequences if and when I fall off the wagon... but is there any reason I should persist with requesting the biopsy be done??? Possibly I am just 'intolerant' or 'allergic'?? any input is greatly appreciated Pat