<<Disclaimer: Verify this information before applying it to your situation.>> Hi... I am a newly diagnosed Celiac. I was confirmed with both the small bowel biopsy as well as very high blood test levels. I have had synptoms for over three years. I have gone on the diet and have been VERY good about what I eat. I have not noticed any difference so they did another small bowel biopsy and there has been No improvement. My villi are FLAT. They now want me to start on Prednisone. I would like to hear for others who have refractory sprue and what they have done! Thanks! Cindy