Olga, I had/have Graves' and finally got off my thyroid medication and have been off for over a year. I went hypo a few times and completely backed off the med (Tapazole), until I went hyper again. This went on for a couple of cycles. Eventually I became fairly stable and when I'd feel like I was getting hypo, I'd back off just a little on the med -- just a very little, maybe 2.5 mg (by splitting my 10mg pills). Sometimes I'd add back on and wait a while and then try tapering again. At the end I was taking about 2.5 mg every two days. This eventually worked for me. It was tapering very slowly and by very small amounts based on how I was feeling. My doctor was very aware of what I was doing and he suggested doing it this way, but I did go even more slowly than he suggested. I don't know if tapering had anything to do with my eventually getting back to normal, but that's how I did it, and it worked. I cannot imagine why you are taking both Tapazole and Levoxyl since they have opposite effects. But then I am not a doctor. One thing that helped me was that my doctor explained that the thyroid can store up thyroid hormone that can last weeks or months. When you get hyper you have a whole lot of hormone stored up. You take Tapazole (or similar drug) and your thyroid slows down making the hormone but you still have vast quantities stored up which your body is using to make you hyper. Then when you finally use that up, your thyroid is so suppressed by the medication that you don't have enough, and you tend to get hypo. Then you back off the Tapazole, ad infinitum, it seems. (I am not saying this is a scientifically correct explanation but it sure did seem to be likely based on what was happening to me.) It is extremely difficult to get regulated because of the delayed effect of the medication due to the storage of thyroid hormone. It can drive patients and their doctors nearly crazy. I have been told that radiation is the "treatment of choice" and I wonder if it is because if you go on and kill the thyroid you don't have to deal with the tremendously extreme swings and difficulty in getting stable, and you don't annoy the hell out of your doctor. But then you are eliminating any chance of recovery. I am glad I waited. I know I am susceptible to a recurrence, but so far things are ok. (Let me emphasize that I am just talking about Graves' -- other thyroid conditions have different pathology.) Anne -- ------------------------------------------------------------------------ [x] None of the Above ------------------------------------------------------------------------ Anne Albright / [log in to unmask] / (919) 677-8000 x6323 / R4335 SAS Institute Inc. / IDB Testing / SAS Campus Drive / Cary NC 27513