In a message dated 97-05-05 23:51:31 EDT, you write: << ow, for my question. Two weeks ago I started on Synthroid (0.05 mg). I want to know if I'm imagining things, or is it really possible to feel the effects of the Synthroid almost immediately? >>>My internist said it would take months to regulate, and probably a couple of months before I would be able to tell a difference. The part I felt the difference in was I had so much more energy and I wasn't nearly as hungry as I usually am. The hair loss is still there, as is the dry skin, joint aches, etc., etc. Now, however, after just a couple of weeks, I feel the fatigue creeping back in. Sometimes I think I've read too much. >> Hi, This is EXACTLY the pattern I experienced. I felt and incredible difference overnight, literally. After a couple of weeks the effects diminished. With each successive dose on the path to my correct dose this pattern repeated itself. My doctor would never bring me to an optimum dose where the fatigue did not creep back in because I tested "normal." Eventually I changed doctors and changed to ARmour. I do much better on that. It is interesting that doctors are so adamant in their wrongheadedness. Rather than say they are not familiar with such a symptom, pattern or whatever they say "No way." No wonder they loose credibility with their patients, ZeeSwan