<<Disclaimer: Verify this information before applying it to your situation.>> Before I knew my saliva was testing positive for gliadins, I had another round of tests that said I needed enzyme therapy. I did experience SOME symptom relief from my intestinal problems from the enzymes (actually, the first in 18 years), but felt even BETTER later on when I obliterated wheat from my diet. So maybe enzyme therapy is a partial help, but not a total answer. My naturopath felt that if you hit a situation where you discovered you had eaten wheat, you should take papain to counteract the bad effects, but that this wasn't an everyday answer, just an emergency thing. Judy Hettena Wright Vermont