<<Disclaimer: Verify this information before applying it to your situation.>> Hi All, Yes, I have had a gluten response from and prescribed skin lotion. I called the doctor, who as usual was clueless, then called the manufacturer. It turned out that one ingredient, sorbitol, was grain based. Skin is our largest organ, and readily absorbs what we put on it. I use an estrogen skin patch and the hormone is easily absorbed into my system. I now am ultra careful with soaps, lotions, and shampoo. I stay away from the obvious, like wheat germ oil, as well as the popular oatmeal soaps. I need to be so careful, as I am one of those people who is sensitive to even a molecule. Ellen, Eugene, Oregon