<<Disclaimer: Verify this information before applying it to your situation.>> Forwarded with permission: To: [log in to unmask] From: [log in to unmask] (Kalle Reichelt) Date: 08/19/96 04:39:59 PM EDT Subject: Downs syndrome Hi. I know nothing about the mechanisms causing the Fanconi syndrome.It is correct that there is s slight increasein the frequency of coeliac disease in Downs. More important though is the fact that without Downs syndrome more than 1/3 of the children have extremely high IgA antibodies against gliadin, gluten,lactoglobulin and casein as well as ovalbumin without endomycium antibodies being increased.(1,2) There is an inverse relationship size of the children and level of IgA to gliadin and gluten. C P Reading in Australia thinks that there is a causal relationship Downs because of the increase in antibodies found also by him (3). Ref: 1:Kanavin \ et al (1988) Immunological studies of patients with Down's syndrome. Acta med Scand. 224: 474-477. 2: Reichelt KL et al (1994) Increased levels of antibodies to food proteins in Down Syndrome. Acta Paed japon 36: 489-492. 3:Reading CM (1984) Down's syndrome:Is Gluten/Alpha-gliadin sensitivity/coeliac disease the cause? Int J Biosocial Res 6: 62-65. All the best Cheers TINY K. Reichelt Pediatric Research Institute N-0027 Oslo, Norway Tel: +47 22 86 90 45 Fax: +47 22 86 91 17 E-mail: [log in to unmask]