<<Disclaimer: Verify this information before applying it to your situation.>> Paul, I read with great interest your post this morning. My family has had a problem with the women all having cycle related migraine headaches that begin at age 30 and last through menopause. After y-e-a-r-s I finally said something that made my Ob/gyn understand why I kept complaining that it related to hormone levels, and he said that there were some people whose uterus became more permeable during certain times of month letting substances (I think he said prostaglandins) leak into the blood that act like a poison to the system. That is exactly the feeling, as if I were being poisoned, with a knot forming on the left side of my neck where the neck joins the skull. My doctor has had me taking Alleve (naproxen sodium) to get some relief (nothing else has ever diminished the pain in the least!). When I beg taking the epsom salts baths, my regular neckache disappeared that occurs on the second day of the month. The mid-month (ovulation, I assume) headache is still troublesome some months, even off of wheat and milk, although I am finding the number of Alleve needed to make the pain bearable has diminished from 4 to 2. It also might be interesting to you, Paul, and maybe to others, that in my daughter Grace's amino acid profile (which I just got back with explanation last week), there was a discussion, because of her profile, of hyperaminoaciduria, or amino acid dumping in the urine. They said, "Ususally the amino acid group transfer, called transamination, is to alpha-ketoglutaric acid which adds the amino group to become glutamic acid. Alpha-ketoglutaris acid, the primary amino group receptor in amino acid metabolisms, is formed in the citric acid cycle. Transamination steps require pyridoxal phosphate (PyrPO4 from vitamin B6) as a coenzyme.....The corresponding symptoms also can be strongly influenced by diet, and can vary from individual to individual and may vary with the specific hyperaminoacidurias. Headaches and occasional nausea are most common.[sound like PMS?] Other symptoms observed to be coincident with hyperaminoacidurias and limited protein tolerance include: fatigue, dizzyness (sometimes vertigo), unusual skin sensations (hot, cold, crawling, tingling, burning, etc.), urticaria, and occasionally the indivdual excretes abnormally high urine volumes...." Another puzzle from my life which might relate is that when Grace was 20 months old, and was reducing her amount of breastfeeding, I suddenly had double vision which lasted about a week. There has been a lot of discussion of weak eye muscles on the autism list, but I thought my double vision was probably caused by some hormonal changes related to weaning my child. Hope this is interesting, and if anyone is interested on this list in seeing Grace's amino acid profile, I'd be glad to share. Seventeen of them were out of normal ranges. I will note, however, that she is not diagnosed celiac, but probably has the gluten intolerance that Paul is researching relative to autism. Susan Owens