<<Disclaimer: Verify this information before applying it to your situation.>> Before I would commit myself to a lifelong dietary change as drastic as is the gluten free diet, I think I would be sure to have a definitive biopsy study done just to be sure. I mean, let's face it, the diet, albeit not impossible to follow, requires a great deal of work, planning, research, time, and effort. It's not something to take lightly, nor is it something that can be started and discontinued when it becomes inconvenient. I think a definitive diagnosis would make one adhere more closely to such strict dietary requirements. Just my 2cents. Heather Murphy