<<Disclaimer: Verify this information before applying it to your situation.>> My sister and I both have CD. She recently has developed severe, unexplained hives. The last episode lasted longer than 1 wk and was very painful. Even after a cortisone shot and ingesting several antihistamines prescribed by a physician, she did not improve. She is now being tested for lupus because her Dr. said hives were a symptom of lupus. Because of problems I have had in the past, I have read quite a bit about lupus and do not remember hives per se being a symptom. In any case, we are wondering whether other people with CD frequently develop hives and whether they seem to be related to gluten ingestion. Since both of us are quite strict about the GF diet, we don't think she is consuming it but 3 episodes of hives in 6 months is a concern. Thanks for any information. Kathy Harden [log in to unmask] Champaign, IL