Steve, Before connecting to the USB port, you need to download and install the Kenwood virtual comm port driver from this site: https://www.google.com/?gws_rd=ssl Follow the instructions about when to connect the cable. It will install as a comm port number which can be changed in windows later if need be. It may install as a very high number (up in the teens). After this, use that comm port for your software connection. This will also activate your internal sound card. It will become the windows default sound card, and some have had problems with losing speech. Be sure your screen reader is using the internal pc sound card and not set to use the "default" card. The serial and usb ports are indipendent and you could use the serial port via a serial to usb adapter without having to install the kenwood driver. But no use of the sound card via the serial port on the radio. 73, Steve KW3A On 9/10/2015 4:23 PM, Steve Dresser wrote: > Hi all, > > I know at least a few folks on this list have connected a TS-590 to a PC = > via USB, and I'd appreciate any guidance from experts on this list. = > Right now, I'm primarily interested in controlling the radio, but later = > on I may want to use the 590's internal sound card. Do I need = > additional drivers to use USB for radio control, or can I just plug and = > play? > > Steve >