Russ - I did re-sync per the MS get started guide as well as rebooted. Didn't help! Just in case, I tried a 5 year old USB MS optical mouse And all worked perfectly. David - You say buy a new mouse - Is there an issue with these wireless devices? I have a mouse keyboard set for convenience but if there are issues with how long these devices last that I am not aware of - I will switch back to wired to eliminate the hassle and the expense. Thanks for your feedback, Dave The NOSPIN Group is now offering Free PC Tech support at our newest website: http://freepctech.com