"Last year alone, doctors wrote 189 million prescriptions for $12 billion of antidepressants ... After 14 weeks, two thirds of patients still hadn't improved ... After 14 weeks, about 25% of the patients who chose to switch drugs and about 30% of the patients who chose to add a drug reached remission." (I read that as at most 22% improved - 2/3 were offered to switch or continue, assuming none chose to simply quit, 30% of 2/3 is just under 20%, that's after 28 weeks, 60% of a year. (There isn't data cited for what percent of depressions might just go away on their own after 28 weeks.) And the message of the story is to stick with it until you find the right drug. Sylvia) Wall St Journal, March 23, D4 "People Who experience mood swings, fear, voices and visions"