I eat sardines virtually every day plus loads of high purine foods ie asparagus, spinach, scallops etc -- my Uric Acid level from my last physical was 4.5. The scale is 1.7-7.5 -- so eating very high levels of purines hasn't given me high uric acid. Lutz and Allen mention in their book Life Without Bread that their patients who had high uric acid levels saw it drop on a low-carb regime and believe that carbohydrates esp. fructose and sorbitol cause a rise in uric acid. Hence, they believe that anyone suffering form high uric acid levels should restrict their carbohydrate. They do acknowledge that some people do see their uric acid rise on a low carb regime and believe that this is due to a metabolic defect. It's not a paleo book per se but I think Life Without Bread is a very good read.