<<Disclaimer: Verify this information before applying it to your situation.>> Microflora and Hesperidin Teamup to Reduce Allergies/Bleeding Intestinal microflora and the bioflavonoid, hesperidin, may work together to reduce allergies. Hesperidin is available from many fruits and vegetables. Malabsorption of hesperidin due to celiac disease or low stomach acid plus the alteration of intestinal microflora may be responsible for a decrease in histamine inhibition and increased allergic reactions, also leading to increased bruising and bleeding conditions such as nose-bleeding and hemmoroids. In particular, I can relate to this. I have been dealing with food sensitivities, rectal bleeding, and I bruise very easily. Perhaps I need to supplement with hesperidin in addition to consuming Nancy's Yogurt. ---------- Info about Hesperidin and Bioflavonoids http://www.acu-cell.com/bio.html ---------- Pharmacology. 2004 Aug;71(4):174-80 Antiallergic activity of hesperidin is activated by intestinal microflora. Lee NK, Choi SH, Park SH, Park EK, Kim DH. School of Oriental Medicine, Kyung Hee University, Seoul, Korea. When hesperidin isolated from pericarpium of Citrus unshiu (family Rutaceae) was incubated with human intestinal microflora, its main metabolite was hesperetin, which was a main metabolite in urine of orally hesperidin-administered rats. The antiallergic activity of hesperidin and its metabolite hesperetin were investigated. Hesperidin did not inhibit the histamine release from RBL-2H3 cells induced by IgE. However, its metabolite hesperetin potently inhibited the histamine release from RBL-2H3 cells induced by IgE and the PCA reaction. The inhibitory activity of hesperetin was found to be comparable with azelastine, a commercially available antiallergic drug, and to potently inhibit prostaglandin E(2) production in lipopolysaccharide-stimulated RAW 264.7 cells. Hesperetin weakly inhibits cyclooxygenase 2 enzyme activities. These results suggest that hesperidin may be a prodrug, which is metabolized to hesperetin by intestinal bacteria. Copyright 2004 S. Karger AG, Basel PMID: 15240993 [PubMed - in process] * * * * Send administrative questions to [log in to unmask] *