<<Disclaimer: Verify this information before applying it to your situation.>> Studies showing that alterations of gut bacteria lead to food and other forms of allergies just keep on piling up in medical journals. It is increasingly clear that allergy, food intolerance and autoimmune disease research needs to be strongly directed towards the association between microflora and tolerance. ---------- Histol Histopathol. 2004 Jul;19(3):907-14 Role of intestinal bacterial flora in oral tolerance induction. Tanaka K, Ishikawa H. Department of Infectious Diseases, Tokai University School of Medicine, Kanagawa, Japan. [log in to unmask] In healthy individuals, the immune responses against foods cannot be induced. This phenomenon is known as oral tolerance. We observed that the oral tolerance was impaired in germfree mice, and that Th2-dependent antibodies such as IgE could be thus induced by an orally given antigen. As a result, the germfree mouse was considered to be a good animal model for allergic disorder. When germfree mice were mono-associated with such bacteria as E.coli and B. infantis, then oral tolerance was restored in these gnotobiotes to a level similar to that observed in SPF mice. Thus, these bacterias seemed to be important in oral tolerance induction. In addition, the probiotics using these bacteria may be a useful material for the treatment of allergic disorders. PMID: 15168353 [PubMed - in process] * * * *Support summarization of posts, reply to the SENDER not the CELIAC List*