<<Disclaimer: Verify this information before applying it to your situation.>> The studies shown do not show a free radical effect by gliadin, but rather that immune cells release free radicals as part of inflammation. These studies serve to bolster the advice to be gluten free if you have celiac disease. The study about gliadin affecting epithelial cells was done in caco-2 cells, which is a tumor cell line. The caco-2 cell line studies are generally considered useful, but a few other cell lines should be tested before drawing conclusions of gliadins likely in vivo effects. Stephen Holland, M.D. *Support summarization of posts, reply to the SENDER not the CELIAC List*