From "interrmitting fasting dissociates beneficial...."
levels of igf-1 were decreased in calorie resricted mice
Increased in interrmitted fasted mice
IF mice were not calorie resricted
Difference suggests a difference in igf-1 axis and insulin
signaling pathway
Insulin level lower in IF than CR reveals a dissociation in mechanisms
regulating IGF-1
and insulin signaling pathway.
Rats with moderate reduction in IGH-1 live longer.
A greater decrease have reduced lifespan.
Suggestig their is a optimal level of GH-IGF-1 axis to
maxiimize lifespan.
IGF-1 is neuroprotective in neurodegenertive disorders.
Decreased IGF-1 proposed to protect against carcinogenesis.
IF protects against tumor growth suggests additional
mechanisms must be operative in this beneficial effect of
IF."
Take a linear appoarc
h to a complex dynamic.
Protein more satisfying than fat
saturated fat causes heart disease
IGF-1 bad
Three strikes your out. BM