From "interrmitting fasting dissociates beneficial...." levels of igf-1 were decreased in calorie resricted mice Increased in interrmitted fasted mice IF mice were not calorie resricted Difference suggests a difference in igf-1 axis and insulin signaling pathway Insulin level lower in IF than CR reveals a dissociation in mechanisms regulating IGF-1 and insulin signaling pathway. Rats with moderate reduction in IGH-1 live longer. A greater decrease have reduced lifespan. Suggestig their is a optimal level of GH-IGF-1 axis to maxiimize lifespan. IGF-1 is neuroprotective in neurodegenertive disorders. Decreased IGF-1 proposed to protect against carcinogenesis. IF protects against tumor growth suggests additional mechanisms must be operative in this beneficial effect of IF." Take a linear appoarc h to a complex dynamic. Protein more satisfying than fat saturated fat causes heart disease IGF-1 bad Three strikes your out. BM