<<Disclaimer: Verify this information before applying it to your situation.>> I recently obtained copies of the following articles of current interest in celiac disease treatment news: Shan, L. et al. Structural basis for gluten intolerance in celiac disease. Science. (2002) 297: 2275-2279. Anderson, R. P., Degano, P., Godkin, A. J., Jewell, D. P. & Hill, A. V. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nature Med. 6, 337-342 (2000). The amino-acid sequence of the gluten peptide identified as the primary cause of celiac disease by Chaitan Khosla and his group in the recent Science magazine article differs from the amino-acid sequence in the gluten peptide identified by Robert Anderson and his Oxford University group in their Nature Medicine article. The two studies differed in the methods used to identify their respective gluten peptides. The two groups also differ in their approaches to a celiac disease treatment. Khosla's approach to a treatment involves using a bacterial enzyme to breakdown the gluten peptide into harmless entities. Anderson's approach involves producing modified peptides to block the T-cell recognition sites, much like antihistamines block histamine receptor sites to prevent allergy symptoms. http://www.ivillagehealth.com/news/drugs/content/0,13607,412636_542652,00.ht ml "The inventors have shown that by modifying the bioactive epitope to produce a number of similar structures, these modified versions will compete with the T-cell recognition site and inhibit the immune response when given with the unmodified, bioactive epitope. These modified peptides could therefore form the basis of a specific therapeutic treatment for coeliac disease." The two research groups will need to resolve the differences in their studies to be sure the proper gluten epitopes are effectively disabled to prevent the celiac disease response. In the meantime, in order to better comprehend the terminology found in these research articles, I have acquired a thick notebook of articles on immunology and recent celiac disease research studies. Most of these articles I obtained freely from the internet, though I suspect copyright violations are involved in posting these articles on websites without obtaining proper permissions. I will be busy reading over the next few weeks, trying to become an "expert" on immunology and celiac disease research. I will share a list of the articles I have obtained and where I got them in a future posting. Here is one very recent and comprehensive overview of celiac disease I found available on the internet. Get it while you can. (You'll need the Adobe Acrobat Reader): Sollid, LM. Coeliac disease: dissecting a complex inflammatory disorder. Nature Reviews Immunology. (2002) 2:647-655. http://www.immunology.no/cd/Sollid_NRI.pdf *Support summarization of posts, reply to the SENDER not the CELIAC List*