<<Disclaimer: Verify this information before applying it to your situation.>> It seems like my first summary brought out all kinds of supporters of Dr Fine, some of whom were quite evangelistic, and some of whom were knowledgeable and quite rational. I did hear a lot about how disgusted some of them were with the medical establishment and especially their incompetency in the matter of celiac (certainly many of us are aware of this disappointment) as well as some irrational accusations that none of them were interested in treating patients with diet since they made no money from that. (sigh) I decided long ago that I had no need to explain problems with accusations of conspiracies or immorality when simple incompetency explained it adequately :) I think the best followup here would not be to send more of the often long letters I received, but to send edited parts of a paper someone sent me that recorded a talk Dr Fine gave. But perhaps I should mention here that two people did write that they had been diagnosed at Baylor where he used to work: one did not know of him at the time and did not encounter anything about him there; the other said her experience was that they seemed to respect his work and the doc she dealt with did not question his testing. In his paper he explains the difference he makes between what he calls "gluten sensitivity" and CD rather well. He also cites some apparently solid studies to back up that choice. I still haven't seen any such documentation for his testing methods, but have to note that he does do it in a practical manner that keeps the costs down and allows those from all over the country to get an assessment. The paper also says: "Because Dr. Fine's research has shown that as many as 40% of all Americans are gluten sensitive, and that 1 in 225 have celiac sprue, a case can be made that everyone in America should be screened for gluten sensitivity." I would not argue that this cannot be true, but I would personally be interested in seeing some documentation for this. I wonder if these figures might be skewed because he is testing only those who already know they have a problem in this area and send him samples. Yet, to be fair, his figures as to how many have full fledged celiac disease seem to be in agreement with the proportion normally reported. I still haven't heard from anyone who knows of an instance where someone sent in samples and were told they were not either gluten sensitive or had CD. I've tried to mention what I still wonder about, but refrain from offering my own personal opinion here since I'm still undecided and open to more information. I hope this helps some out there to shape their own opinion as to whether or not to work with Dr. Fine in the future. -vance Here are some edited parts of Dr Fine's paper: Traditional Definition of Celiac Disease Dr. Fine offered the traditional definition of Celiac Disease in order to make a distinction between that traditional definition and "gluten sensitivity." Celiac disease (CD) is caused by ingestion of wheat, barley, rye and oats that contain gluten and a subfraction gliadin and prolamines. Physicians look for symptoms or signs due to malabsorption of fluids, electrolytes or nutrients; small intestinal histopathology (indicating damage on a biopsy); inflammation, broad and shortened crypts, intra epithelial lymphocytes, villus atrophy; and clinical improvement on a gluten-free diet. If someone is gluten sensitive and goes on to become a celiac, they have a genetic signal that tells the inflammatory cells to multiply, to send those into the layer of cells on the tips, which leads to damage of the villi. The villi are responsible for absorbing fluid and nutrients and the crypts and inflammatory cells are responsible for secreting fluids. If you take away the absorbing structure and increase the secreting structures, you end up with malabsorption and eventually diarrhea. The disease progression would usually show itself in weight loss, malabsorption of nutrients, diarrhea, abdominal symptoms, etc. Now we have certain tests that can identify gluten sensitivity well before the patient suffers severe digestive symptoms. [one paragraph cut off at the end for brevity] [He cites the following study as evidence] "Gluten Sensitive Diarrhea Without Evidence of Celiac Disease", Cooper et al. Gastro 1980; 79:801. This research paper confirmed that the celiac patients had explosive watery nocturnal diarrhea, lost weight, no appetite, abdominal pain, but none had steatorrhea or malabsorption, and all had normal blood tests. When they looked at the biopsies, the villi were totally normal. There were some increases in inflammatory cells. The doctors put the patients on a gluten-free diet and all patients improved. [He also cites this study as evidence] "Gluten-Sensitive Disease with Mild Enteropathy," Picarelli et al, Gastro 1996; 111:608. Through blood screenings these doctors identified ten patients who had the antiendomysial antibody. These patients had chronic diarrhea or steatorrhea, or iron deficiency, or osteoporosis, mouth ulcers, low calcium in the blood or high liver function tests, which all can be due to gluten sensitivity. They did a d-xylose test which should be normal if you have normal absorption, but 6 out of 8 were abnormal. On a biopsy, the villi were normal, but they did have slight increases of the intra epithelial lymphocytes. Further, they put the biopsy samples into a petri dish, added a substrate of gliadin, and discovered the tissue responded to gliadin. They put these patients on a gluten-free diet; all their symptoms and abnormalities resolved. Therefore, this study showed that you can have gluten sensitive disease with mild enteropathy that does not fit the official criteria for celiac disease.