<<Disclaimer: Verify this information before applying it to your situation.>> Bisquick Substitute 8 cups Flour 1 1/4 cups Nonfat Dry Milk Powder 1/4 cup Baking Powder 1 Tablespoon Salt 2 cups Shortening Combine flour, milk, baking powder, and salt in a very large bowl. Cut in shortening until it resembles coarse cornmeal. Store in tightly closed covered container in a cool place. Makes about 10 cups.