<<Disclaimer: Verify this information before applying it to your situation.>> How about the old tried and true? I have been taking Premarin 1.25mg a day, every day, since 1977 due to surgery. NEVER a problem. My doctor was an excellent one and prescribed these particular ones because I was Celiac and advised me to never, ever change brands of estrogen nor touch a generic in this case. Yes, I am wretchedly sensitive. Sandy Rieser Fort Worth, TX