<<Disclaimer: Verify this information before applying it to your situation.>> I wasn't sure exactly how often to take Lactaid pills, so I emailed them and asked. Here's their reply. It's pretty helpful, more so than their box!! PS Lactaid Ultra Caplets are gluten free. The chewables are NOT. Dear Joanna- Thanks for visiting our website. Once Lactaid (TM) Caplets and Lactaid (TM) Ultra Caplets and Chewables are ingested with the first bite of food, the lactase enzyme will be active for approximately 30-45 minutes. You should use Lactaid (TM) every time you eat diary foods. You can use it every day with every meal, if you'd like. We will send you a coupon and information via regular mail for your future use