<<Disclaimer: Verify this information before applying it to your situation.>> Has anyone had any trouble with medicines not taking affect with having CD. I have had allot of pain and the doctor prescribe darvcet and it work a couple to times. Now it does not work. Yesterday I had to have colonscopic done at the hospital, they gave me Demerol and something else. It never put me to sleep on relax me just a little. I could still fill some pain. The doctors and nurses were amazed with the amount they gave me I never went to sleep and saw the whole procedure being done. Never did go to sleep that day. just felt groggy. Even my sleeping medicine does not work. If this an intolerance to medicine or I have build up a tolerance to these medicine. Dianne