<<Disclaimer: Verify this information before applying it to your situation.>> Dear Kim -- I was diagnosed in 1963 by biopsy, after being very ill for many years. Along with the digestive problems I also was always very itchy -- legs, arms, back, buttocks. When I was first diagnosed my doctor prescribed Dapsone and I was on it for six months when she decided my skin had cleared. I was living in upstate NY at the time. The itches eventually all came back. I have gone through several series of Prednisone, but my current doctor has not felt I should use Dapsone again because of the side effects. Right now I take 1 mg of Prednisone every other day and just try to control the urge to scratch. I have found I break out in hives whenever I take Tylenol and all the many other acetaminophen medications. I discovered this through trial and error. Excess heat, fatigue and stress will start a scratching episode.