<<Disclaimer: Verify this information before applying it to your situation.>> Does anyone take estrace hormone replacement or climara patch? And if so which is the best and if they are gluten free? Dianne Thanks for all suggestions, If anyone has any more information please continuing sending. I take Estratest and the Climara patch. Both are gluten free. Lisa Due to a complete hyst. when I was 28 I have been on HRT for 8 years now. I have tried just about all of the patches and even tested one brand for the manufacturers. I am currently taking Climara with no problems except a rash if I don't rotate the site often enough. The rash is only from irritation though. I prefer the Climara patch because it stays on better than some other, is smaller in size and does not make any noise when you bend over, lol. I have had some that make a crinkling and crackling noise from the plastic when you move or touch it. Take care! Janna PS I also prefer the patch because I only have to take it once a week. Easier to remember! Natural hormones from women's international pharmacy are the best and safest. 800-279-5708 I used them for years. I have used Estraderm patches for several years with no problem. I tried the ones you change once a week and they gave me a rash. I also couldn't tolerate oral estrogen but it wasn't a cd type reaction. Linda in Iowa USA I use a hormone replacement and have used a form of hormone replacement since 1987. I use premarin white 0.625mg with no dye. I have to make sure that this is no red #40 dye in the hormone replacement or in any other products I use cause it has gluten in that red #40 dye. I tried to use a patch estraderm 0.1mg/ estradiol transdermal system, but couldn't use it cause of the adhesive having gluten in it. I hope this has been some help to you. I take Premarin, estrogen replacement. It is GF. Renee C I take estrace. Have for a number of years. I checked and it was gluten free when I first started taking it and assume it still is. I have no problems with it. I tried the patch (not sure which one) first but got a rash around the site so my dr. said that I was probably allergic to the delivery system and switched me to Estrace which she said is easier on the system than the other hormone pills available. Hope this helps I've been on Premarin 0.625 mg for over two years with no problems. Good Luck! I take estratest and have had no problems with it. I don't know which is best, but I take estrace and have taken it for about 7 years with no problem.