Unique Identifier
  20220887
Authors
  MacDonald HB.
Institution
  Dairy Farmers of Canada, Montreal, Quebec.
Title
  Conjugated linoleic acid and disease prevention: a review of current
  knowledge. [Review] [52 refs]
Abbreviated Source
  J Am Coll Nutr.  19(2 Suppl):111S-118S, 2000 Apr.
Local Messages
  CURRENTLY RECEIVED AT SOUTH LIBRARY
Abstract
  Conjugated linoleic acid (CLA), a derivative of a fatty acid linoleic acid
  (LA), has been reported to decrease tumorigenesis in animals. CLA is
  unique because unlike most antioxidants which are components of plant
  products, it is present in food from animal sources such as dairy foods
  and meats. CLA concentrations in dairy products typically range from 2.9
  to 8.92 mg/g fat of which the 9-cis, 11-trans isomer makes up to 73% to
  93% of the total CLA. Low concentrations of CLA are found in human blood
  and tissues. In vitro results suggest that CLA is cytotoxic to MCF-7 cells
  and it inhibits the proliferation of human malignant melanoma and
  colorectal cancer cells. In animal studies, CLA has inhibited the
  development of mouse epidermal tumors, mouse forestomach cancer and rat
  mammary cancer. Hamsters fed CLA collectively had significantly reduced
  levels of plasma total cholesterol, non-high-density lipoprotein
  cholesterol, (combined very-low and low-density lipoprotein) and
  triglycerides with no effect on high-density lipoprotein cholesterol, as
  compared to controls. Dietary CLA modulated certain aspects of the immune
  defense but had no obvious effect on the growth of an established,
  aggressive mammary tumor in mice. It is now thought that CLA itself may
  not have anti-oxidant capabilities but may produce substances which
  protect cells from the detrimental effects of peroxides. There is,
  however, insufficient evidence from human epidemiological data, and very
  few of the animal studies have shown a dose-response relationship with the
  quantity of CLA feed and the extent of tumor growth. Further research with
  tumor models is needed to test the efficacy and utility of CLA in cancer
  and other disease prevention and form the basis of evaluating its effect
  in humans by observational studies and clinical trials. [References: 52]